Hypothalamic damage refers to a series of symptoms caused by hypothalamic damage due to various causes, mainly endocrine metabolic disorders with dysfunctional syndrome of the vegetative nervous system, including sleep, body temperature, feeding, sexual dysfunction, uremia, and psychiatric abnormalities. Pay attention to the treatment of complications, such as gastrointestinal bleeding, etc. Special attention should be paid to the prevention and treatment of hypertonic and hyperglycemic non-ketotic coma, which has a poor prognosis and a high mortality rate if not treated in time. For tumor-induced hypothalamic damage, surgical resection and radiotherapy can be used; for inflammation, antibiotics should be used; drugs caused by drugs should be stopped immediately; those affected by other systemic diseases should be treated for the original disease; those caused by psychiatric factors need psychiatric treatment. In cases of hypopituitarism, hormone replacement therapy can be provided according to the degree of hypopituitarism; in cases of urolithiasis, dihydrocotinine and antacid can be used, and in severe cases, intramuscular injection of urolithiasis can be used; in cases of overflowing breast, bromocriptine can be used; in cases of gonadotropin deficiency, chorionic gonadotropin combined with testosterone propionate can be used; in Kallmann syndrome, pulsed GnRH therapy can be used. The “artificial hypothalamus”: a portable microinfusion pump is used to simulate the pulsed release of GnRH, and LHRH analogs are injected into the body at regular intervals. Hypothalamic fever can be treated with aspirin and other antipyretic or physical cooling methods as well as artificial hibernation.