Anti-inflammatory drugs for treating toothache are commonly available such as cefixime, amoxicillin capsules, metronidazole, etc. However, not all toothaches need to be treated with medication, and many cases require filling, root canal, scaling, or rinsing and medication. Most of the toothache is the reaction of the nerve of the tooth caused by bacterial infection, mainly Streptococcus pyogenes, if it is periodontitis, wisdom tooth pericoronitis, can be combined with oral anti-inflammatory drugs such as cefixime, cefaclor, amoxicillin capsules, metronidazole or ornidazole and so on. Metronidazole is more effective against anaerobic infections. Drug treatment of toothache is only to relieve the symptoms and auxiliary role, and can not solve the root cause of toothache, pulpitis, apical periodontitis need to carry out root canal treatment, gingivitis caused by toothache need to scaling medication to relieve the pain, wisdom teeth peri-coronary inflammation need to carry out local rinsing and medication, deep caries should be filled. Therefore, do not take medication on your own when you have a toothache, you need to go to the dentist to find out the cause and then accept the doctor’s treatment, and if you need to take medication, you should follow the doctor’s instructions strictly.