The difference between viral herpes and hand, foot and mouth disease is mainly in terms of the causes, symptoms and other aspects. 1. Causes: Viral herpes is usually caused mainly by herpes simplex virus and herpes zoster virus infection, while hand, foot and mouth disease is mainly caused by enterovirus infection. 2. Symptoms: The viral herpes that needs to be differentiated from hand, foot and mouth is mainly erythema or papules occurring on the face, corners of the mouth, perineum and other parts of the skin and mucous membranes, and then there will be clusters of pinpoint-sized blisters, which are prone to breakage. Hand, foot and mouth disease is mainly manifested in the hands, feet, mouth, buttocks and other parts of the skin and mucous membrane of the single papule, blisters, pimples, ulcers, etc., often accompanied by fever, fatigue symptoms. As both are caused by viruses, the treatment usually requires antiviral therapy, in addition to targeted treatment for the patient’s own symptoms, due to individual differences, so the significance of comparison is not great. It is recommended that patients should seek medical attention if they experience any of the above symptoms.