The biggest side effect of rivaroxaban is bleeding, and it is important to take care of increased monitoring during the course of medication. Rivaroxaban exerts its anticoagulant effect by inhibiting coagulation factors, and is clinically used in the treatment of a variety of thrombotic disorders, such as the treatment of deep vein thrombosis of the lower extremities, pulmonary artery embolism, and atrial fibrillation in non-valvular disease. Adverse reactions of rivaroxaban include bleeding, dizziness, nausea, transaminase elevation, etc. However, the most common and largest adverse reaction is bleeding, most patients are bleeding from the skin mucous membranes, a small number of patients will occur in the gastrointestinal tract, the urinary tract, and a very small number of patients can occur intracranial hemorrhage, which can jeopardize the patient’s life safety. Allergy to rivaroxaban drug components, severe hepatic impairment, active bleeding, lactation and pregnancy women are prohibited. During the course of taking rivaroxaban, you should pay attention to monitoring the adverse reactions of the drug, and if necessary, adjust the drug under the guidance of the physician.