In clinical treatment, there is no strict limitation on the number of times antibiotics can be used in a year, but there are generally recommendations for dosage and maximum duration of use, and the principles of antibiotic use should be strictly followed. Antibiotics, or antibacterial drugs, are complex, involving antibacterial drugs, antifungal drugs, antimycoplasma or chlamydia drugs. Different types have different mechanisms of action. The use of antibiotics needs to strictly follow the indications. They can be used to treat well-defined bacterial or fungal infections of the type (bacterial pneumonia, fungal pneumonia) and to prevent possible infections, such as category II incisions in gastrointestinal surgery. The number of uses is in principle not strictly limited, and the type of antibiotic needs to be rationally selected. However, prolonged use of the same antimicrobial drug should be avoided in order to avoid drug resistance, etc. If part of the drug has the longest recommended course of treatment, in the course of treatment according to the standardized dosage of drugs and still no significant improvement should be considered to replace the drug rather than continue long-term use. Long-term antibiotic abuse, may lead to the body flora imbalance, causing gastrointestinal reactions. It can also lead to the development of drug-resistant bacteria, etc., resulting in the deterioration of the effectiveness of antibiotics, which may lead to real infections, there is no bacterial sensitivity of antibiotics can be used. Clinically, although there is no strict limit on the number of times antibiotics can be used per year, antibiotic treatment needs to strictly follow the indications for use, to avoid prolonged use of the same antimicrobial drug and unreasonable use. The use of drugs should be under the guidance of specialized doctors.