Whether chemotherapy for breast cancer is effective or not for six times is related to the specific condition, pathology, treatment effect, etc. It is recommended to have standardized treatment. Breast cancer belongs to systemic disease, and the treatment is based on surgery as the main comprehensive treatment, which includes radical surgery, postoperative adjuvant chemotherapy according to the condition, some need to cooperate with radiotherapy, and some need endocrine therapy, targeted therapy, etc. It is common to do chemotherapy for six times, and it doesn’t mean that the treatment is over after six times of chemotherapy. If patients have axillary lymph node enlargement, they also need to be treated with adjuvant radiotherapy. If the immunohistological examination of estrogen receptor and/or progesterone receptor positive breast cancer, it is also necessary to cooperate with endocrine therapy, and some tests are eligible for targeted drugs, targeted therapy can also be carried out. All in all, breast cancer requires comprehensive treatment, as well as regular review, observation of changes in the condition, and timely consultation if there is any discomfort, so as to clarify the diagnosis and treatment.