Otitis media pain can not sleep, most of the acute suppurative otitis media, tympanic membrane is not perforated when caused, according to the degree of progress of the disease need to be taken systemic treatment, local treatment and other methods to control the disease, relieve symptoms, there is no quick relief method. 1. Systemic treatment: early and timely use of drugs, penicillin as the first choice of drugs, at the same time can be combined with acetaminophen, ibuprofen and other pain medication to relieve symptoms. 2. Local treatment: the tympanic membrane is not perforated can be used locally glycerol carbolic acid, pain relief and anti-inflammatory effect, tympanic membrane perforation should not be used; tympanic pus, not perforated should be incised tympanic membrane to facilitate drainage, and to prevent complications. Otitis media pain can not sleep, should go to the regular hospital in time for examination, specific treatment measures need to be carried out under the guidance of a doctor, to avoid abusing drugs.