Clinically, we often find that the common side effect of tumor patients after applying targeted drug therapy is dry and cracked hands and feet, while the skin of face or torso rarely appears dry and cracked. What are the reasons for such a phenomenon? From the Western medicine point of view, firstly, it is because of poor blood circulation at the end of the limbs, and secondly, it is because the skin keratinization layer is slow to proliferate, while the muscles inside grow fast, and the fast-growing muscles hold the skin open, which makes it easy for cracks to appear. The conventional treatment in Western medicine is to soften the keratinized layer and then tear off the hard skin of the keratinized layer. And how does Chinese medicine view dry and cracked skin on hands and feet? In terms of TCM thinking, insufficient yin and blood cannot moisten the four ends, so the skin will be dry and cracked. In clinical practice, I project from the five movements and six qi that people with dry and cracked hands and feet also tend to be dehydrated. Then why is there a local water deficiency or Yin-Blood deficiency? I think it is because Qi, blood and fluid cannot be transported properly to the ends of the extremities. There are two reasons for this, one is the power problem, which is blamed on the lung, which is the master of the skin and hair, and the lung qi is unfavorable, so it cannot distribute qi, blood and fluid to the whole body, and dryness is connected to the lung qi, which also indicates that dry and cracked hands and feet are closely related to the lung; the other is the stagnation of meridians, so it is also unable to transport qi, blood and fluid to the ends of the limbs, which is the understanding of dry and cracked hands and feet from the perspective of Chinese medicine. Here is how to regulate this condition with Chinese medicine 1, you can use raw earth, xuan ginseng to nourish kidney water, replenish Yin and blood, and raw astragalus to benefit Qi and produce fluid; 2, use lily, mulberry leaf and almond to moisten the lung, clear the lung, and promote the lowering of lung qi to facilitate the distribution of Yin, blood and fluid to the extremities, and also to get rid of dryness; 3, then add the cooling blood and activating blood medicine comfrey to unblock the meridians; 4, because of the cracked hands and feet, add white and to promote wound healing. Combining the above four points, here is the integrated prescription, Sheng Di 30g, Xuan Shen 15g, Sheng Huang Qi 30g, Lily 10g, Mulberry Leaf 10g, Bitter Almond 6g, Comfrey 15g, Bai He 10g, water decoction for external washing, 1 dose daily, here the prescription is for reference only. According to our clinical observation, patients generally feel that their hands and feet are smoother in about three days, the fissures start to close in about a week, and the effect can be basically relieved in about two to three weeks, which is remarkable.