Blisters on the corners of the mouth wipe toothpaste did not help, blisters on the corners of the mouth is divided into herpes keratitis, bacterial keratitis two cases, as follows: first, herpes keratitis: this situation is mainly due to the herpes virus infection caused. For herpes keratitis, you need to use antiviral drugs, the most clinically used is acyclovir ointment, usually pay attention to the corners of the mouth hygiene, drink more water, keep the corners of the mouth localized clean, dry. Second, bacterial keratitis: for bacterial keratitis, you need to use antibiotic ointment, such as gentamycin ophthalmic ointment, erythromycin ointment and so on. At the same time, eat more fruits and vegetables, and keep the local cleanliness and hygiene of the corners of the mouth. Avoid opening your mouth widely when corns are present to prevent further damage to the corners of the mouth.