Hepatocellular carcinoma is prone to cancer fever, which is often intermittent, without chills or chills, and lasts for a long time. Occasionally, persistent high fever is seen without obvious toxemia symptoms. This kind of cancer fever is sensitive to antipyretic drugs such as anti-inflammatory pain, naproxen and corticosteroid, but the fever starts again after stopping the drugs, which is easy to be misdiagnosed as tuberculosis, typhoid fever and connective tissue disease, thus delaying the correct diagnosis. The principle of cancer fever may be due to the pyrogen or tumor necrosis factor produced by the cancer tissue itself or infiltrated leukocytes. However, conversely, infection must also be excluded from the diagnosis. Primary liver cancer often occurs on the basis of cirrhosis. According to statistics, at least 80% of liver cancers are accompanied by cirrhosis, and about 15% to 75% of liver cancers are eventually caused by cirrhosis. Therefore, patients with cirrhosis, especially those infected with hepatitis B and C viruses, should be highly alert to the occurrence of liver cancer and should undergo relevant examinations regularly. In addition, when admitting patients with cirrhosis complicated with upper gastrointestinal bleeding, doctors often focus on hemostatic measures and prevention of hepatic coma, but neglect patients who may already have hepatocellular carcinoma (especially diffuse hepatocellular carcinoma), which leads to misdiagnosis or underdiagnosis. About 10% of patients with hepatocellular carcinoma die due to rupture and bleeding of the cancer mass, which can be due to external force or spontaneous rupture. If it is confined to the subperitoneum of the liver, severe right upper abdominal pain will occur. If ruptured into the abdominal cavity, acute abdomen will appear. In addition, spontaneous peritonitis is easy to occur in middle and late stage hepatocellular carcinoma, which is also very easy to be misdiagnosed. The digestive symptoms of some liver cancer patients mainly consist of diarrhea, which can be easily misdiagnosed as chronic enteritis or malabsorption syndrome. Diarrhea can also be the first symptom of liver cancer. According to some statistics, diarrhea is the first symptom of 5.8% of 3254 liver cancer patients. Diarrhea is the most common associated cancer syndrome in liver cancer patients, with an incidence rate of 10%-30% (17.4% according to Shanghai Liver Cancer Research Institute), and it is easy to be misdiagnosed when liver cancer is not detected. It is easy to be misdiagnosed when liver cancer is not detected. The cause of this syndrome may be mainly related to the ectopic production of insulin by hepatocellular carcinoma cells. In severe cases, this disease may lead to coma, shock and death.