The regulation of upper heat and lower cold (heat in the upper part of the body and cold in the lower part) should be warming the upper part of the body and clearing the lower part of the body, using Wu Mei Wan with additions and subtractions, or acupuncture and moxibustion, with medication and acupoints chosen according to the doctor’s instructions. Heat on the upper part of the body and cold on the lower part of the body refers to the condition where the upper part of the body manifests heat while the lower part of the body manifests cold. Symptoms include bitter taste in the mouth, heartburn, burning heat in the stomach and epigastrium, distension and painlessness, dry vomiting and vomiting, cold limbs, intestinal tinnitus and diarrhea. The treatment of this syndrome is to clear the upper part and warm the lower part. It can be used as prescribed by the doctor with the addition and subtraction of Wu Mei Wan, etc. The formula composition consists of Wu Mei Pork, Huang Lian, Huang Bai, Huajiao, Xin Xin, Gui Zhi, Gan Jiang, Pian Zi, Ginseng, Angelica Sinensis and so on. The adverse reactions and contraindications of this product are not clear. Acupuncture can also be used for treatment, such as selecting acupuncture points such as Neiguan, Zhongkou, Ashigaru, Yanglingquan, and Yinlingquan. Moxibustion can also be used, moxibustion Shenque, Foot Sanli, Spleen Yu, Qihai and other points. Specific operations should be carried out by specialized physicians. If the patient is not feeling well, it is recommended to consult a doctor in time to identify the cause of the disease and standardize the treatment.