Generally, the second dose of DPT vaccine is more reactive, but each child’s body condition is different, and only a very small number of children will react, and most children will not have any adverse reactions. A total of four doses of DPT vaccine are required. Generally speaking, the reaction to the second injection is larger, probably because the body has produced certain antibodies after the first injection, and the antibodies have taken effect after the second injection, which may lead to a larger reaction. However, not all children will have an adverse reaction, and only a very small number of children will have an adverse reaction. After receiving DPT5 vaccination, adverse reactions such as localized redness, swelling, hot pain and itching of the skin or transient increase in body temperature may occur. However, most children’s body temperature does not exceed 38.5℃, and they can recover by themselves through physical cooling and rest. When the body temperature exceeds 38.5 ℃ need to take oral antipyretic drugs under the guidance of a physician, such as high fever for more than 24 hours without relief, the emergence of other obvious discomfort, it is recommended to go to the hospital.