The main goals of comprehensive treatment for colorectal cancer bone metastases are: (1) to relieve pain, restore function and improve quality of life; (2) to prevent or delay the occurrence of bone-related events. (3) control tumor progression and prolong survival. Bone metastases from colorectal cancer, as recurrent metastatic cancer is already a systemic disease, the treatment options include: (1) pain medication; (2) bisphosphonate therapy; (3) radiation therapy; (4) surgery; (5) symptomatic support and rehabilitation; (6) chemotherapy, molecular targeted therapy and other anti-tumor treatments. To relieve the symptoms and complications caused by tumor metastases, improve the quality of life, and control the progression of tumor disease, it is often necessary to receive a combination of treatment methods.