Thermoregulatory disorders are fevers resulting from abnormalities in the thermoregulatory center due to central nervous system pathology. Thermoregulatory disorders are rare among the various causes of fever, and their manifestations and management are different from those of common infectious and other causes of fever. Therefore, when determining the central fever, the first step should be to exclude infectious, pharmacologic, and other causes of fever. Some patients are often in a state of depression and anxiety, which can also cause thermoregulation disorders. What are the causes of thermoregulatory disorders: Pediatric hypoglycemia Hypoglycemia refers to the lower than normal blood glucose concentration caused by different reasons. The blood glucose of newborns drops to the lowest point 1~2h after birth, then gradually rises, and the normal plasma glucose should be >2.8mmol/L (>50mg/dl) at 72h. Blood glucose <2.2mmol/L (<40mg/dl) in newborns is considered hypoglycemia, and fasting blood glucose <2.8mmol/L (<50mg/dl) in older infants and children is considered hypoglycemia. Aggressive treatment should be started when blood glucose <2.24mmol/L (<40mg/dl) in newborn infants. Hypoglycemia can cause irreversible damage to the brain and affect brain function. Craniopharyngioma: It is a common embryonic remnant tissue tumor developed from the epithelial cells of the remnants of the craniopharyngeal duct formed in the ectoderm, and is the most common intracranial congenital tumor, which is more common in children and less common in adults, mostly in the suprasellar area. Its main clinical features include hypothalamic-pituitary dysfunction, increased intracranial pressure, visual acuity and visual field disorders, uveitis, and neurological and psychiatric symptoms. The main treatment is surgical removal of the tumor. Anxiety disorder (ANXIETY): also known as anxiety neurosis, is the most common type of neurological disorder in this broad category, characterized by the experience of anxious emotions. It can be divided into two forms: chronic anxiety, i.e. generalized anxiety, and acute anxiety, i.e. panic attack. The main manifestations are: nervousness and worry without a clear objective object, fidgeting, as well as symptoms of plant nervous dysfunction, such as palpitations, hand trembling, sweating, frequent urination, etc., and motor restlessness. Note the distinction between normal anxiety, which may be pathological if the severity of anxiety is clearly inconsistent with the objective facts or situation, or if it lasts for too long. Hypothalamic disorders: A group of disorders in which hypothalamic function is impaired due to various reasons, mainly characterized by endocrine dysfunction and plant nervous dysfunction. The hypothalamus is both a high-level phytocenter and a high-level endocrine center with complex functions. The hypothalamus has a very close relationship with pituitary function, gonadal activity, thermoregulation, appetite control and water metabolism. Depression: also known as depressive disorder, with significant and persistent depression as the main clinical feature, is the main type of mood disorder. The depressed mood can range from sullenness to grief, low self-esteem and depression, and even pessimism and anxiety, and there can be suicide attempts or behaviors; even wood stiffness; some cases have obvious anxiety and motor agitation; severe cases can have hallucinations, delusions and other psychotic symptoms. Each episode lasts for at least 2 weeks, or even several years, and most cases have a tendency to have recurrent episodes, most episodes can be relieved, some may have residual symptoms or become chronic.