Acipimox and pitavastatin can be used together, but be careful to review liver function. Acipimox belongs to lipid-lowering drugs, the main component is hydrochloric acid derivatives, for both cholesterol and triglyceride lowering effect, but the main effect is to lower triglyceride; Pitavastatin is a cholesterol-lowering drugs, mainly inhibit the synthesis of cholesterol, for the mixed hyperlipidemia, the two can be used at the same time, but pay attention to the review of the function of the liver. Adverse reactions of Acipimox include flushing, dizziness, fatigue, stomach upset, rash, etc. It is contraindicated in patients with allergy to drug components, active ulcers, lactating pregnant women, and severe renal impairment. Adverse reactions to pitavastatin include nausea, vomiting, dizziness, joint pain, muscle aches, elevated transaminases, etc. It is contraindicated in patients with allergy to drug components, unexplained elevation of liver enzymes, and severe hepatic impairment. In clinical practice, adverse reactions will increase with the combined use of lipid-lowering drugs, and should be used under the guidance of a physician, not blindly on their own.