Treatment methods for papillary duodenal cancer include pancreaticoduodenectomy, radiotherapy, chemotherapy, percutaneous intrahepatic bile duct puncture and external drainage. 1. Pancreaticoduodenectomy: Duodenal papillary carcinoma is a kind of malignant tumor in digestive system, and the treatment needs to be chosen according to the typing of the tumor itself. The preferred treatment is pancreaticoduodenectomy, supplemented by other auxiliary treatments such as radiotherapy and chemotherapy. 2. Radiotherapy and chemotherapy: mainly can treat patients with advanced metastasis and improve the success rate of surgical resection, which also belongs to the auxiliary treatment after surgery and is more suitable for patients with lesions left after tumor resection. 3. Percutaneous intrahepatic bile duct puncture and external drainage: in case of jaundice and abdominal pain caused by biliary obstruction, patients can choose percutaneous intrahepatic bile duct puncture and external drainage to alleviate the symptoms of obstruction and improve the quality of life. If patients are diagnosed with duodenal papillary carcinoma, please choose the treatment plan under professional doctor’s guidance and actively treat it, make sure to pay attention to diet hygiene and avoid overeating.