There are more varieties of topical creams used for the treatment of vitiligo, which mainly include glucocorticoid drugs, calcium-modulated phosphatase inhibitors, vitamin D3 derivatives and so on. 1. glucocorticoid drugs: these drugs have a strong anti-inflammatory effect, help to restore the color of the skin, and at the same time help to slow down the progression of the disease, commonly used drugs are hydrocortisone butyrate cream, betamethasone valerate cream, fluticasone propionate cream and so on. Adverse reactions mainly include hirsutism, capillary dilatation, skin atrophy and so on. 2. Calcium-regulated phosphatase inhibitors: this is a class of topical drugs that play an immunosuppressive role by inhibiting calcium-regulated phosphatase, commonly used tacrolimus ointment, pimecrolimus cream and so on. Adverse effects include burning, stinging and itching of the skin. 3. Vitamin D3 derivatives: these drugs can inhibit the proliferation of skin cells, and can induce their differentiation, commonly used drugs are carbotriol ointment, tacalcitol ointment and so on. A few patients may experience temporary local irritation discomfort after using the drug. Vitiligo patients are advised to consult the dermatology department of the hospital, in order to ensure the safety and effectiveness of the medication, be sure to strictly comply with the doctor’s instructions for the use of drugs.