Gestational combined diabetes mellitus includes: diabetes mellitus in pregnancy and diabetes mellitus found or occurred during pregnancy. The early diagnosis and strict control of glucose in pregnancy can significantly improve the prognosis of mother and child. Pregnancy is contraindicated in patients with severe cardiac and renal complications or proliferative retinopathy, and should be terminated as soon as possible in those who are already pregnant. However, pregnancy is possible for those with proliferative retinopathy who have been treated with photocoagulation. Since glucose-lowering drugs are teratogenic and may cause fetal hypoglycemia, the use of glucose-lowering drugs should be stopped 3-6 months before pregnancy and insulin should be used to control blood glucose. Second, the treatment of pregnancy 1, diabetes screening by the placenta hormones, pregnancy pon insulin needs increased, such as the body of pregnant women can not be correspondingly increased insulin production, there will be glucose metabolism disorders, the occurrence of gestational diabetes mellitus (GDM). Usually, pregnant women are given 50g of glucose orally at 24-28 weeks of gestation, and their blood glucose is measured 2 hours after taking the glucose (called glucose screening). 7.8mmol/L is considered abnormal for glucose screening, and then the diagnosis is further determined by 75g glucose tolerance test. If the blood glucose (11.1mmol/L) is measured at 1 hour after sugar screening, it is possible to check the spatial blood glucose directly. For pregnant women at high risk of diabetes mellitus, glucose screening is performed at the first prenatal checkup. (2) Diabetes treatment includes dietary management and insulin treatment, maintaining fasting and blood glucose before three meals at 3.3~5.6mmol/L, blood glucose 2 hours after three meals at 4.4~6.7mmol/L, and zero point blood glucose at 4.4~5.6mmol/L. (1) Dietary management Gestational combined diabetes requires 300 kcal more per day than non-pregnancy. Carbohydrates account for 50% to 55% of the total daily calories, protein accounts for 25% and fat accounts for 20% to 25%. The main meals should be small and frequent. Given that the body produces the highest concentration of insulin orange anti-hormone in the early morning. Pregnant women with diabetes should have a small amount of breakfast, with 1/10 of the whole day’s calories, and should eat foods containing less carbohydrates, and 30% of the whole day’s calories for lunch and dinner; the rest of the calories should be made up by the second meal. After 3 days of strict dietary control, the blood glucose “profile test” should be reviewed, i.e. monitoring the blood glucose at zero, before three meals and 2 hours after three meals to understand the effect of dietary control. (2) Insulin treatment After diet control, if the extravagant blood essence does not reach the ideal range, insulin treatment should be added. There is no specific formula for adjusting insulin dosage for reference because of the large difference in insulin sensitivity of different individuals during pregnancy. Before using insulin, we should understand the metabolic characteristics of various insulin dosage forms in detail and choose insulin dosage form and dosage according to the blood glucose level of the profile test. Commonly used insulins are long-acting insulin and common insulin, and generally long-acting insulin is used to control nighttime and fasting blood glucose, and common insulin is used to control postprandial blood glucose. After normal blood glucose control, blood glucose should be rechecked at least once a week (including fasting and before and/or after three meals). Timely adjustment of insulin dosage with the progress of pregnancy insulin dosage should be increased, such as a sudden decline in insulin dosage during pregnancy, often indicates placental hypoplasia. At the same time, high blood circulation is likely to cause fetal hypoxia, and in serious cases, fetal death will occur in utero, among which diabetic ketosis is the most harmful to the fetus, so monitoring should be strengthened. The fetus of diabetic women often has delayed lung maturation, so amniotic fluid should be taken in late pregnancy to check the maturation of fetal lung, and dexamethasone should be injected into the amniotic cavity at the same time to promote fetal lung maturation. In cases of diabetes mellitus with vascular disease, regular electrocardiogram, renal function and fundus should be checked. The timing of termination of pregnancy should be determined by the diabetic condition, the presence of comorbidities and the functional status of the placenta. If diabetes is combined with vascular disease, hypertension or placental hypoplasia and the fetus is mature, the pregnancy should be terminated in time, or if the glucose control during pregnancy is satisfactory, the pregnancy can be terminated before the expected delivery date. Diabetes mellitus is not an indication for cesarean delivery, but fetal monitoring should be enhanced during labor. Long-acting insulin should be stopped one day before termination of pregnancy. The mother and child with diabetes mellitus have a high incidence of comorbidities. After birth, pay attention to keeping warm, preventing infection and monitoring blood sugar, and feeding as early as possible to prevent neonatal hypoglycemia, closely observe whether there is neonatal respiratory distress syndrome and erythrocytosis, etc. On the first day after delivery, review maternal fasting blood essence and guide insulin dosage. Gestational diabetes mothers should be followed up regularly after delivery.