Puffiness of the eyelids in the morning needs to be determined according to the actual situation, if one eye appears to be swollen eyelids, it may be caused by mosquito bites, allergies, or eye diseases. If the eyelids are swollen bilaterally, the local cause is allergy or eye disease. After excluding localized lesions, the most likely cause is systemic lesions. Before diagnosing systemic lesions, it is necessary to rule out special circumstances, such as drinking too much water before going to bed, which is not completely excreted during the night, or endocrine metabolism disorders during menstruation, which cause bilateral eye swelling. After excluding the above situation is the systemic disease caused by bilateral eyelid swelling, such as kidney disease, heart disease and so on. In addition to swelling of the eyelids, kidney diseases also have bilateral edema of the ankles, increased foam in the urine, which does not disappear in a short period of time. Heart disease is often associated with symptoms of heart failure or arrhythmia, and a cardiac ultrasound and electrocardiogram can help in the differential diagnosis.