Elderly nephropathy with leg swelling is usually related to diabetic nephropathy, glomerulonephritis, hypertensive renal small arteriosclerosis and other diseases, which can be treated with medication and renal substitution therapy according to the etiology, and reasonable oral diuretics are also needed to reduce swelling. 1. Diabetic nephropathy: mainly related to diabetes mellitus, it should insist on taking oral hypoglycemic drugs to control the condition, such as metformin, and injecting insulin. When renal function is affected and renal insufficiency occurs, renal replacement therapy, such as hemodialysis, peritoneal dialysis, and renal transplantation, can be considered. When edema is serious, oral furosemide diuretic can be taken. 2. Glomerulonephritis: If it belongs to acute glomerulonephritis, it needs to be treated as soon as possible to protect the kidney and reduce the degree of renal injury, and plasma replacement can be considered to prevent the decline of blood volume if necessary. When the degree of leg swelling is serious, hydrochlorothiazide and furosemide can be taken orally. When renal function is seriously affected, hemodialysis and peritoneal dialysis can be considered. 3. Hypertensive renal atherosclerosis: need to deal with the primary disease as soon as possible, such as oral captopril, enalapril and other drugs to lower blood pressure and control edema. When renal function is affected, hemodialysis and peritoneal dialysis can be considered. If the elderly found to have kidney disease caused by leg swelling, need to understand the type of kidney disease, then targeted treatment, and timely removal of disease-causing factors, the specific treatment should be carried out under the guidance of a professional physician, not unauthorized use of drugs.