Plasma donation is done by separating the plasma through a blood separator and then transfusing the remaining red blood cells back into the donor. Plasma donation can enhance the body’s hematopoietic function to a certain extent, but there are also certain disadvantages, mainly due to adverse reactions caused by the excessive amount of plasma donated, or briefly affecting the coagulation function, etc. A. Benefits of plasma donation: The main benefit of plasma donation is to enhance the hematopoietic function. Human blood is composed of plasma and blood cells. The bone marrow is the main organ of blood production. Plasma donation can stimulate the bone marrow and keep it alive for hematopoiesis, so to a certain extent, plasma donation can enhance the hematopoietic function of the human body. Second, the disadvantages of plasma donation: the most common one is the possibility of affecting the coagulation function. Since plasma accounts for 55% of whole blood, after a large amount of plasma donation, it may transiently affect the coagulation function of the body, resulting in slower wound clotting, which usually improves after a period of recuperation. In a few cases, there may be other adverse reactions. A small number of people may have adverse reactions due to the excessive amount of plasma donated. Mild manifestations include pallor, dizziness and sweating, moderate manifestations include chest tightness and palpitations, nausea and vertigo, and severe manifestations include low blood pressure, hand and foot twitching and fainting. It is recommended to calculate the amount of plasma to be donated according to one’s own weight and to follow the arrangements made by professionals in order to avoid the above-mentioned adverse reactions from overdose. Generally speaking, healthy people who meet the requirements for blood donation and donate the standard amount of blood will not have adverse reactions and the human body has a strong self-regulatory ability and usually returns to normal after a period of rest. Therefore, after blood donation, it is important to take rest, avoid straining, and eat iron-rich foods such as lean pork, beef, and animal liver in appropriate amounts to help the body recover.