Itching between the testicles and the thighs considers a variety of conditions, starting with the possibility of ringworm, which is caused by a fungal infection and manifests locally as annular erythema, on which scales can be seen in an eccentric and expanding trend, with small local blisters. The diagnosis can be confirmed by fungal microscopy or fungal culture, and topical antifungal medications, such as terbinafine cream, can be chosen. If topical antifungal medication is not effective, oral antifungal medication, such as fluconazole, can be used. Consider also the possibility of inter-rub rash, which is mainly due to repeated friction between skin and mucous membrane, resulting in local erythema, vesicles, and even oozing. You can use topical glucocorticoid creams when there is no exudation, and you can choose to use topical zinc oxide paste when there is exudation, and usually keep the area dry and breathable to reduce sweating.