Typical manifestation of SLE disease in active stage is a group of clinical combination of symptoms, which includes systemic symptoms, skin and mucous membrane symptoms, joint and muscle symptoms, hematologic symptoms, renal system and neurological symptoms. 1. Systemic symptoms: such as fever, fatigue, weight loss, lymph node enlargement, etc. Fever is the most common systemic symptom, accounting for 92%, and prolonged low fever is common. 2. Skin and mucous membrane symptoms: such as facial erythema, photosensitivity, alopecia, oral ulcers, Raynaud’s phenomenon, etc. 80%~85% of SLE patients have skin rashes. 3. Joint and muscle symptoms: there is joint swelling and pain, but usually does not cause bone destruction. Muscle involvement may manifest as myalgia and muscle weakness. 4. Hematological symptoms: there are thrombocytopenia, leukopenia, anemia, etc. Severe anemia occurs in a short period of time, and there are mostly elevated reticulocytes. 5. Kidney symptoms: it will be manifested as lower limb edema, elevated blood pressure, etc., with abnormal renal function or even renal failure. 6. Neurological symptoms: they may manifest as headache, memory disorder and personality change, which often appear in the acute or terminal stage. SLE can involve multiple organs and systems, and the manifestation of the disease varies from patient to patient, so the disease can also involve digestive, respiratory, cardiovascular and other systems. It is recommended that SLE patients should have regular outpatient follow-ups to detect disease activity and intervene in a timely manner.