Chemotherapy 8 times how many times the maximum reaction of different patients have different reactions, most of the patients after several times of chemotherapy reaction gradually aggravated, some patients for the first time the maximum reaction. Chemotherapy 8 times how many times the maximum response is not completely fixed, but most patients will increase with the number of chemotherapy and the response gradually aggravated, chemotherapy drugs have a certain accumulation, after repeated chemotherapy patients gradually weakened, liver and kidney function and hematopoietic system gradually damage, the patient’s response is more and more serious, but there are some patients with the first response to the heavier. Specifically the first reaction should also consider the patient’s own tolerance, chemotherapy adverse reactions are more, the patient should strengthen the care, the relevant manifestations of timely medical treatment, regular review.