Gallbladder Colonic Hepatic Flexure Adhesion Syndrome is a series of symptoms that occur when the bottom of the gallbladder adheres to the hepatic flexure of the colon and the colon forms an acute angle through which intestinal contents do not pass, resulting in a buildup of gas in the hepatic flexure of the colon and when the colon forms a pull on the gallbladder. Risk factors for gallbladder-colon hepatic flexure adhesion syndrome include cholecystitis, gallbladder stones, or adhesions after gallbladder and colon surgery. It often presents with dull pain in the right upper abdomen, nausea, loss of appetite, bloating, acid reflux, vomiting, and stiffness of the right abdominal wall muscles. The site of pain is adjacent to the liver region and should be differentiated from hepatobiliary diseases. If there are symptoms such as dull pain in the right upper abdomen, abdominal distension, frequent constipation, etc., gastroenteroscopy and abdominal ultrasound should be done in time to make a clear diagnosis. If there is any of the above discomfort, it is recommended to actively seek medical treatment to avoid delaying the condition.