Transverse colon, descending colon pressure pain with grunting common causes are gastroenteritis, gastrointestinal bleeding, mechanical intestinal obstruction, ulcerative colitis, treatment methods are anti-infective such as amoxicillin, levofloxacin and other drugs, surgery, immunosuppressive drugs such as azathioprine treatment. 1. Anti-infective treatment: applicable to patients with gastroenteritis, clinical manifestations of abdominal pain, nausea and vomiting, leukocytosis, intestinal hyperphonia. Commonly used antimicrobials are amoxicillin, levofloxacin, and so on. 2. Surgical treatment: it is suitable for patients with serious organic lesions, such as intestinal malignant tumors, severe mechanical intestinal obstruction. Mechanical intestinal obstruction manifests itself as persistent and enhanced abdominal pain, vomiting, cessation of defecation and hyperactive bowel sounds, and in severe cases, there will be water-electrolyte disorders and peritonitis, which should be relieved from obstruction by timely surgery. 3. Anti-inflammatory, immunosuppressive therapy: for patients with ulcerative colitis. Ulcerative colitis is characterized by left lower abdominal pain, mucopurulent blood stools, and hyperactive bowel sounds. The basic drug is salicylazosulfapyridine, the use of salicylic acid drugs and glucocorticoids is ineffective patients, need to use immunosuppressive therapy, commonly used drugs such as azathioprine. It is recommended that patients with pressure pain with gurgling in the descending colon of the transverse colon consult a doctor in time to find the cause of the disease and then carry out professional treatment.