High anti-thyroglobulin antibodies suggest a possible thyroid disorder, such as Hashimoto’s thyroiditis (chronic lymphocytic thyroiditis) or diffuse toxic goiter (Graves’ disease), etc. The cause of the disease needs to be clarified before treatment can be targeted. If Graves’ disease is the cause of high antithyroglobulin antibodies, anti-thyroid medication, iodine 131, or surgery may be the treatment of choice. 1. Chronic lymphocytic thyroiditis is an autoimmune disease. For those who present with hypothyroidism, the main treatment is to take levothyroxine replacement therapy, and thyroidectomy can be performed if there are compression symptoms or malignant changes are suspected. 2. Graves’ disease is also an autoimmune thyroid disease, and the treatment includes antithyroid drugs, iodine 131 and surgery. Antithyroid drugs include imidazoles (e.g., methimazole) and thiouracils (e.g., propylthiouracil). Patients with high anti-thyroglobulin antibodies are advised to seek medical advice from a medical professional to avoid delays.