Pain is a sensation and experience that everyone has had, yet a comprehensive scientific definition of pain is rarely known.In 1979 the International Association for the Study of Pain (IASP) defined pain as “an unpleasant sensation and emotional feeling that accompanies existing or potential tissue damage, pain is often subjective, and everyone learns the exact words to express pain early in life through the experience of injury. The exact words to express pain are learned through the experience of injury, which is undoubtedly a local or global sensation in the body, and is also always an unpleasant emotional feeling”. People’s understanding of pain and the degree of attention also have a lot to do with it. In outpatient clinics, we often encounter patients who chatter to the nurse during the infusion, constantly asking where to tie and which hand to tie. So when a person is highly tense, the pain symptoms also increase with the change of mood. To treat painful diseases, one must also take note of the factors that affect patients’ emotions, so effective psychological care for pain patients to help them overcome negative psychological factors will have a great therapeutic effect. First: create a good medical environment for patients ward quiet and clean, fresh air, good ventilation, suitable temperature and humidity, avoid all kinds of adverse stimulation, fully ensure that the patient sleep. Make patients feel comfortable to enhance the psychological treatment effect. Second: Harmonious nurse-patient relationship is the key to psychological care for pain patients. Nurses should be kind and generous to patients, treat them equally, make them feel safe during hospitalization and have a sense of trust in medical personnel. Nurses should treat patients with compassion, even if they have excessive emotions, they should not ignore them, they should understand patients’ emotional reactions when they are in pain, and they should explain the causes and laws of pain to patients, so as to reduce anxiety and depression to achieve the effect of reducing pain. Third: deep breathing for pain relief. Medical personnel can instruct patients to take a deep breath and then exhale slowly, and when breathing, close the eyes and imagine that fresh air enters the lungs slowly, and instruct patients to conduct meditation and relaxation training, so that they can learn to change the excitability of the plant nerves with their thoughts to enhance the body’s ability to regulate external stimuli. Fourth: distraction. Such as accompanying patients more, communicating with them more, listening to their words more, placing some magazines in the consultation room, and organizing some medical health lectures so that their bodies can relax well can all play a role in reducing the pain of their diseases. Encourage patients to record emotional management diary, share and exchange with patients, provide a place for venting bad emotions to help patients open their minds, identify problems and correct them in time, so that patients can be relieved from mental pain. Fifth: Seek the cooperation of family members. The family’s words and actions directly affect the patient’s psychology, often the family’s positive attitude and stable emotions will bring twice the effect with half the effort, while treating the patient’s disease, the family should also participate in it, which can also dynamic understanding of the disease, at any time can find the patient’s emotional problems, timely feedback to the medical staff, is also a good way to reduce pain.