1. Lifelong anticoagulation is required after mechanical valve replacement and 6 months after biologic valve replacement; anticoagulation treatment generally uses oral warfarin. 2. At present, the common warfarin is divided into imported and domestic dosage, the dose of imported dosage is 3mg per tablet, and the domestic model is usually 2.5 mg per tablet. 3. During the anticoagulation treatment, the prothrombinogen time should be rechecked regularly, and the result of the examination will give the international normalized ratio (INR), and the dose of warfarin should be adjusted according to the international normalized ratio. Target value of anticoagulation (INR): Mechanical mitral valve 1.8-2.2 Mechanical aortic valve 1.6-2.0 Mechanical tricuspid valve 2.5-3.0 Biological valve 1.5 It takes 2-3 days for warfarin to take full effect, and the prothrombinogen time examined on the same day reflects the effectiveness of warfarin taken orally 2-3 days ago. Warfarin sodium reaches a stable blood concentration about 7-14 days after administration.The dose of warfarin needs to be increased when the INR is lower than the target value, and conversely, reduced when the INR is higher than the target value. Consult your doctor for specific adjustments. If you adjust the dose or change the dosage form, please note that the prothrombin time should be rechecked until the INR stabilizes within the target value. 4.During the period of taking warfarin, do not eat a lot of vitamin K-rich foods or drugs, vitamin K-rich foods include leeks, carrots, spinach, tomatoes, animal liver; vitamin K-rich drugs, including multivitamins, some of the blood tonic drugs (application of the need to consult a doctor). 5, life to avoid bumping and other injuries, such as nosebleeds, bleeding teeth, bumping the skin after a large bruise, should be promptly to the local hospital, timely review of coagulation function, so as to avoid overdose of drugs. And inform your doctor that you are taking warfarin sodium for valve replacement to avoid delay. If you need to undergo other surgeries, you should also inform your doctor that you are taking warfarin sodium for heart valve replacement surgery. 6. If you need to take other medications, please read the instructions for the medication to see if it has any effect on warfarin.