There is no authoritative information to show that taking blocking medication will affect the window period of HIV (Human Immunodeficiency Virus) infection. The window period of HIV infection is the period between HIV infection and the time when antibodies can be detected in the blood. According to the current testing methods, the window period of HIV infection is between 2 and 6 weeks, and the exact time varies from person to person. There is no research data to show that taking blocking drugs will affect the HIV window period. It is recommended that patients can take tenofovir, emtricitabine and other blocking drugs after the occurrence of high-risk behavior, which can reduce the risk of HIV infection. It is recommended that patients seek medical attention after engaging in high-risk behaviors, and under the guidance of the doctor for examination and treatment.