After allogeneic stem cell transplantation, because there should be GVHD reaction, there should be rejection, because the late infusion of stem cells can lead to T-cell activation, then we should use anti-rejection drugs, as follows: 1, the first choice is glycodermic hormone, generally short-acting is methylprednisolone, the onset of action is faster; 2, prophylactic drugs can be used cyclosporine has an inhibitory effect on T-cells, from 1 day before transplantation onwards application If GVHD is relatively heavy, such as target organ damage is relatively heavy, you can add some relatively expensive drugs, such as CD25 antibody for monoclonal antibodies, which can block T-cell damage to organs, but the price is relatively expensive. You can also use FK506, which is an immunosuppressant, but because of the relatively large side effects. So most of the rejection drugs choose hormones, and other immunomodulators such as methotrexate and cyclosporine are more commonly used. If the disease is more severe and the family is slightly better off, antibodies can be used to block it.