The antiviral method for chronic hepatitis B virus infection status can be interferon, but interferon treatment must start with liver function that is not too obvious abnormally and must not progress to a significant degree of cirrhosis. Continuous application of interferon has the potential to remove the hepatitis B virus completely, however, the associated side effects are also more numerous. Long-term injection of interferon can lead to low white blood cell counts, which can easily lead to infections, and it can also cause a flu-like reaction with recurrent fever. Therefore, regular review and symptomatic treatment are needed. The most commonly used antiviral method for hepatitis B is oral nucleoside analogs, which corresponds to much fewer adverse reactions. However, oral nucleoside analogs do not achieve complete clearance of the hepatitis B virus, and must be taken for a long period of time, and there is a possibility of drug resistance. Currently the most commonly used drug is entecavir, you can also choose tenofovir, taking this drug at the same time also need to regularly review, to determine whether the virus has not appeared drug-resistant situation.