Gastric sinus erosion with low-grade intraepithelial neoplasia may be caused by poor dietary habits, Helicobacter pylori infection and other factors. 1. Bad dietary habits: unclean diet, overeating, spicy and stimulating food, cold food, etc. will damage the gastric mucosa, leading to gastric mucosal inflammatory cell infiltration, and then the development of the disease, as well as untimely treatment of gastric sinus erosion. 2. Helicobacter pylori infection: Helicobacter pylori will secrete toxins, infringement of the gastric sinus mucosa, followed by inflammation, and even gastric sinus erosion, ulcers and other manifestations. Therefore, gastroscopy can show gastric sinus erosion with low-grade intraepithelial neoplasia. There are many other causes of gastric sinus erosion with low-grade intraepithelial neoplasia, which should be treated promptly under the guidance of a doctor.