A centipede bite with localized swelling is an insect bite reaction, also known as insect bite dermatitis. Patients can get relief through local treatment, medication intervention and home care. 1. Local treatment: After being bitten by a centipede, because the venom of centipede is acidic, soapy water can be used for rinsing. For localized swelling, ice packs can be applied to reduce localized pain and swelling. 2. Pharmacological intervention: If the patient is accompanied by obvious local itching and pain symptoms, the patient can cooperate with the doctor to choose oral loratadine, cetirizine and other drugs to improve the local metamorphosis. In order to prevent secondary bacterial infection after scratching, fusidic acid, mupirocin ointment can be chosen to apply treatment. 3. Family care: patients in the treatment period, need to avoid eating spicy, greasy, cold stimulating food, do a good job of personal hygiene at home, eliminate mosquito breeding environment. Appropriate exercise can be carried out to enhance one’s physical fitness. After being bitten by a centipede, it is recommended to consult the dermatology department of the hospital, and it is recommended to use medication under the guidance of the doctor, and not blindly self-medication, so as to avoid adverse effects.