Patients who always wake up at 2-3 o’clock in the middle of the night are considered to have sleep disorders. Patients may have some psychological and mental stress, emotional anxiety or tension, which causes them to wake up at 2-3 o’clock in the middle of the night. Patients may also have some bad habits, such as playing with cell phones after waking up in the middle of the night, which will lead to the disturbance of biological clock after a long time, and it will be easy to wake up at 2-3 o’clock at night, and it will be difficult to fall back to sleep after waking up. For this situation, first of all, we should adjust our lifestyle, develop the habit of regular work and rest, and participate in more physical activities during the day, so that the body is in a slightly fatigued state, for better sleep quality at night. The second is that patients can take oral sedative sleeping drugs, long-acting diazepam, estradiolam to adjust sleep.