A woman’s natural fertility begins to decline after the age of 35, and although many women are still fertile after the age of 40, usually, most women have completely lost their fertility years before menopause. Although Assisted Reproductive Technology (ART) can solve many fertility-related problems for infertile couples, it cannot compensate for the regrets of all families. The advanced age of women undergoing IVF and the decline of their ovarian reserve are the main reasons for IVF failure. All women should be aware of the objective fact that advanced age causes a decline in fertility. Obstetricians and gynecologists are obliged to educate every woman who intends to have a baby after the age of 35 about the relevant science and inform women about the characteristics of their body’s biological clock. 1. Women over the age of 35 need to know the fact that their chances of conception are significantly lower than those of the younger age group. The chances of conception for each menstrual cycle of women over the age of 40 are only 1/100, and if they have not yet conceived after 6 months of active attempts, a more proactive approach would be to consult with a specialist in reproductive medicine to receive the necessary medical assistance. 2. For women over the age of 40, doctors are obliged to inform elderly mothers of the risks of pregnancy, including the relatively high risk of miscarriage, the increased risk of pregnancy complications, such as surgical delivery, diabetes, intrauterine growth restriction, and low-birth-weight babies, and the need for pre-pregnancy screening for certain diseases, such as diabetes and high blood pressure. 3. If conditions permit, both partners undergo a comprehensive physical examination that includes preconception testing. Obstetrics and gynecology should include: gynecological examination, cervical cytology screening (currently mainly TCT), ultrasound examination of the uterus and both adnexa. If finances allow, it is recommended to screen for high-risk HPV and TORCH testing at the same time. 4. Start taking one 0.4mg folic acid tablet daily three months before the planned pregnancy until three months after successful conception. If it is an unplanned pregnancy and you have not supplemented folic acid in advance, as long as you are not an extremely paranoid or severely malnourished woman, don’t be overly alarmed and start taking it in a timely manner. 5. For women with regular menstruation, maintaining regular sex (2-3 times/week) since the last clean menstruation will help increase the chances of conception. Medical science defines the 6 days before ovulation as the “window of conception”, if you can maintain a frequent sex life within these 6 days / 1-1-2 days will get the greatest chance of conception. 6, if the sex life is not so frequent, or couples living in two places, one often travel, it is recommended to master some appropriate methods of predicting ovulation, such as measuring the basal body temperature, the use of ovulation test strips, etc., will help to improve the rate of conception. 7. Once you have successfully conceived, you should undergo prenatal checkups as early as possible. Pregnant women over 35 years old are medically known as high-risk pregnancies, with an increased risk of delivering a fetus with chromosomal abnormalities/malformations, so you should start prenatal checkups before the third trimester, to give your doctor sufficient time to discuss with you and provide you with prenatal diagnostics (e.g., NT measurements or chorionic villus biopsy, Down’s syndrome screening, and amniocentesis if necessary, to detect a fetus with chromosomal abnormalities early). chromosomal abnormalities in the fetus). 8. Healthy eating, exercise and a regular routine need not be emphasized. Whether or not you have children, a woman will benefit for the rest of her life if she is able to do this all the time. For example, avoid smoking, excessive alcohol consumption, drinking too much coffee, taking drugs, and coming into contact with poisons or harmful chemicals. 9, about the mode of delivery: advanced age is not an absolute indication for cesarean section, it is recommended that before pregnancy to develop a healthy diet, regular exercise, a good lifestyle, exercise during pregnancy, weight control, to avoid oversized fetus, if there is no contraindication to vaginal delivery, the advanced age of women as well as can be normal delivery. 10, Finally, it should be noted that older fathers seem to increase the risk of spontaneous abortion, certain autosomal dominant genetic disorders, autism spectrum disorders, and schizophrenia. If the man is older than 40, he should be counseled about these possible risks, even though they are small.