The difference between Ligliptin and Metformin mainly lies in the method of use, mechanism of action, adverse reactions, such as Ligliptin taking time is flexible while Metformin needs to be taken with meals, Ligliptin’s most common adverse reaction is allergy while Metformin is gastrointestinal reaction. 1. Method of use: Riglitazide taking time is more flexible, usually once a day, a fixed time every day, and the effect of the drug is not affected by the diet, meals, before or after meals can be taken; metformin easy to gastrointestinal adverse reactions, it is recommended to take with meals, the number of times per day vary. 2. Mechanism of action: Ligliptin belongs to the class of dipeptidyl peptidase-IV inhibitor hypoglycemic drugs, which can promote insulin secretion by increasing the level of GLP-1 in the body; metformin belongs to the class of biguanide hypoglycemic drugs, which can inhibit hepatic glucose output, increase the utilization of glucose by peripheral tissues, and increase the sensitivity of insulin. 3. Adverse reactions: the most common adverse reaction to Ligliptin is allergic reaction (urticaria, angioedema, etc.), in addition to elevated liver enzymes, upper respiratory tract infections, pancreatitis, etc.; metformin is the most common adverse reaction to digestive tract reactions, in addition to skin allergies and lactic acidosis. Diabetic patients must strictly follow the doctor’s instructions to take medication.