Long-term heavy alcohol consumption can cause elevated homocysteine, which is at low levels in the human body under normal physiological conditions and is a sulfur-containing amino acid, a metabolite of the metabolic process of methionine. Deficiencies of folic acid, vitamin B12, vitamin B6 and related enzymes can lead to elevated homocysteine. Relevant studies have shown that homocysteine is an independent risk factor for the occurrence of cardiovascular and cerebrovascular diseases, and homocysteine in the blood can increase the incidence of coronary heart disease and stroke when it exceeds normal values. Elevated homocysteine is also associated with geography and the use of related drugs, such as methotrexate and carbamazepine, and there is a gradual increase in homocysteine in the blood as age increases. Studies have shown that long-term heavy alcohol consumption can also lead to elevated homocysteine in the blood, but the exact mechanism is not clear. If elevated homocysteine is found in the blood, active symptomatic treatment with vitamin B12, folic acid, vitamin B6, etc., as well as improving lifestyle is also very important, such as proper daily exercise, quitting smoking and alcohol, etc.