After taking methotrexate mouth caused by mouth ulcers, mainly through the general treatment and medication to relieve the symptoms, aggravated under the guidance of the doctor to stop treatment. 1. Patients with mouth ulcers should pay attention to the amount of water, eat more vitamin-rich vegetables and fruits, reduce the consumption of seafood, and keep the stool and mouth moist. Maintain a regular routine, avoid overwork and so on. 2. Common therapeutic drugs include oral ulcer powder, vitamin tablets, corticosteroid tablets and so on. The main role is used to control inflammation, relieve symptoms; frequent occurrence of mouth ulcers, patients can use vitamins to relieve symptoms; for patients with painful symptoms of mouth ulcers, corticosteroid tablets can reduce pain and accelerate the healing of ulcers. 3. If the ulcer symptoms worsen or do not heal for a long time, you should consider whether to discontinue the medication under the guidance of your doctor. If you find that taking methotrexate leads to mouth ulcers, you should consult a doctor in time, under the guidance of the doctor’s treatment, not unauthorized use of drugs, so as not to delay the condition. Take care to stay hydrated, eat more fruits and vegetables, and maintain a regular routine.