Post-comatose diffuse cerebral hemorrhage should be treated aggressively using medication, surgery, and wakefulness promotion therapy under doctor’s supervision. Drug therapy can be used under the guidance of doctors to reduce cranial pressure with glycerol fructose, mannitol, hypertonic salts, etc., hemocoagulase, white-browed snake venom hemocoagulase, etc. in order to stop bleeding, and olanzapine, cytarabine, etc. in order to promote the metabolism of brain cells and the restoration of neurological function. Patients with more severe cerebral hemorrhage can also be treated with surgical procedures, such as removing hematoma, removing bone flaps to decompress, and extracerebral ventricular drainage, which can achieve effective reduction of intracranial pressure. There are many ways to promote awakening treatment, usually the doctor will choose one or more methods according to the patient’s condition, such as hyperbaric oxygen to promote awakening, drugs to promote awakening, acupuncture points to promote awakening, and so on. With the dual treatment of etiology and symptomatic wakefulness promotion therapy, most patients can wake up. It is recommended that patients with diffuse cerebral hemorrhage after coma should go to the hospital promptly and follow the medical advice.