Typically the bivalent vaccine costs $361 a shot, but there can be geographic variations. The bivalent vaccine is generally effective for about 10 years, and there are also individual variations. The bivalent vaccine refers to the bivalent HPV (human papillomavirus) vaccine, which mainly prevents HPV 16 and 18 subtypes, and needs to be administered under the guidance of a doctor. The general price of the bivalent HPV vaccine is $361 a shot, but there are some variations due to geographical differences. Existing studies show that the vaccine is effective for about 10 years after the full course of vaccination, but this varies from person to person. The bivalent HPV vaccine requires a total of three injections, and after vaccination, you should pay attention to proper rest, not strenuous exercise and exertion, and try to eat a light diet. If there are slight redness, swelling and hard nodules at the vaccination site, there is no need to worry too much, and it will usually return to normal in 1-2 weeks. Since the effect of the vaccine on pregnancy is not clear, pregnant women and lactating women are prohibited from receiving the vaccination, and should take contraceptive measures when having sex during the vaccination period to prevent unintended pregnancy.