Itchy hands and feet at 39 weeks of pregnancy may be caused by intrahepatic cholestasis of pregnancy, gestational liver injury, skin allergies and other reasons. 1. Intrahepatic cholestasis of pregnancy: it is a unique complication that occurs in the middle and late stages of pregnancy, and may manifest as itching without skin damage, which may begin in the palms and feet, and then spread to the whole body, and may be accompanied by mild jaundice, which may be diagnosed by combining with the clinical manifestations and the measurement of serum bile acids. 2. Liver injury during pregnancy: it may also cause itchy skin symptoms, such as itchy palms and feet, accompanied by gastrointestinal symptoms such as loss of appetite, which can be diagnosed by combining with the history and liver function tests, liver and gallbladder ultrasound and other tests. 3. Skin allergy: can also cause itchy hands and feet, can also be accompanied by localized rashes, mostly eat seafood or have a history of contact with allergens, combined with medical history and clinical manifestations can be diagnosed. 39 weeks pregnant itchy hands and feet need to go to the hospital in time to identify the cause and actively deal with.