Entecavir is an anti-hepatitis B virus drug that generally needs to be taken for a long period of time and should not be discontinued at will. If the drug is stopped at will, it may lead to a rebound of the virus and even the risk of heavy hepatitis. Therefore, patients who use entecavir must discontinue the drug under the guidance of a physician if they want to do so. For hepatitis B, the most important treatment is antiviral therapy, which can effectively inhibit viral replication, reduce infectiousness, improve liver function, and can reduce the incidence of cirrhosis and liver cancer. The antiviral treatment cycle is relatively long, usually at least 4 years, and some may require lifelong medication. When using antiviral drugs, you need to pay attention to monitoring changes in liver function, hepatitis B DNA and quantitative hepatitis B five indicators.