Numbness in the middle of the middle finger of the thumb can be caused by peripheral nerve damage, cerebrovascular disease and other reasons. Numbness in the middle of the middle finger of the thumb is due to a problem with the sensory nerves innervating these two fingers, which belongs to the category of peripheral nerve disease. The sensory nerves innervating the upper limbs are composed of branches of the ulnar-radial nerve, and the sensory nerve conduction from the skin endings through the hands, wrists, elbows, shoulders, neck and finally converge to the cervical plexus, and then into the cranial transmission to the sensory cortex. Any lesion in this pathway that affects the nerve may cause numbness and pain in the fingers. Common conditions include cervical spondylosis, carpal tunnel syndrome, and so on. In addition, cerebrovascular lesions can also cause these symptoms, such as cerebral infarction, cerebral hemorrhage and so on. Patients may also suffer from headache, dizziness, nausea and vomiting at the same time. It is recommended that if the numbness in the fingers persists without relief, the patient should consult a doctor as soon as possible and be given reasonable diagnosis and treatment under the guidance of a professional doctor.