Taking propylthiouracil can reduce liver damage by appropriately reducing the dosage, seeking alternative treatment, and adding liver-protecting drugs. 1. Reduce the dosage appropriately: Antithyroid drug propylthiouracil is metabolized in the liver, so it can cause liver damage. After monitoring the liver function and finding mild liver damage, the dosage can be reduced appropriately, so as to reduce the liver damage. 2. Seek other treatment modalities: you can switch to other antithyroid drugs such as methimazole, and consider iodine 131 treatment or surgical treatment for hyperthyroidism in patients with severe liver damage. 3. Add liver-protecting drugs: you can take glycyrrhizic acid diamine, reduced glutathione, biphenyl dibenzoate, adenosine and other liver-protecting drugs at the same time as propylthiouracil. Pay attention to the use of drugs under the supervision of a physician, breastfeeding, severe liver damage, granulocyte deficiency and allergy to this drug is prohibited. Adverse reactions such as rash, headache, arthralgia, jaundice, granulocytopenia and abnormal liver function may occur.