Skin symptoms of taking amoxicillin allergy vary from person to person and can manifest as hives or drug dermatitis lesions. Amoxicillin allergy can lead to urticaria-like damage to the skin, which manifests itself in the form of flushed, flaky windswept bumps that are visibly itchy. Clinical manifestations of measles-type or scarlet fever-type drug rash may also occur, i.e., diffuse pinpoint-sized red papules all over the body, predominantly on the trunk, with petechiae in severe cases. Individual severe allergy can appear diffuse purplish red or dark red patches, epidermal laxity, with eye, mouth and gastrointestinal mucosal damage, accompanied by fever, liver and renal function abnormalities and other symptoms of systemic toxicity, such as untimely treatment, can lead to death. Amoxicillin is a penicillin antibiotic with antibacterial activity against Streptococcus pneumoniae and Escherichia coli. Adverse reactions such as diarrhea, nausea, and rash may occur after use. This medication should not be combined with drugs such as probenecid. People who are allergic to amoxicillin and penicillin are prohibited from using this drug. The drug should be used in accordance with the doctor’s instructions, and in the event of an allergy to amoxicillin, it is recommended to seek medical attention for targeted treatment or therapy.