Cold medicine and painkillers are not recommended to be taken together. Cold medicine is usually mainly for the relief of the cata-like symptoms of cold, such as headache, fatigue, muscle aches and pains, etc. The main symptom relief in their compound preparations are acetaminophen. Painkillers contain ingredients such as ibuprofen, acetaminophen, aspirin, etc. These drugs have similar ingredients or the same ingredients, and all have certain antipyretic and analgesic effects. If you take cold medicine and painkillers at the same time will increase the side effects of the drugs, causing different degrees of damage to the intestinal tract, such as causing nausea, vomiting, diarrhea and other side effects. Cold medicine and painkillers are also metabolized by the liver, so if too much is taken, it will increase the burden on liver function and may induce drug hepatitis in serious cases.