Whether or not it matters if your creatinine is at a critical value depends on the cause of the elevated blood creatinine. If the creatinine is at the critical value due to a transient increase in blood creatinine, there is no need to worry too much at this time and it can return to normal. However, if the creatinine is at the critical value due to kidney disease, the creatinine may rise further and even develop into kidney failure. The common transient creatinine elevation is often seen when the patient did not pay attention to rest before the blood test of kidney function and was more tired, or some patients may have eaten too much meat or greasy food, which can lead to creatinine fluctuations. In addition, some acute renal failure factors, for example, can also cause creatinine to rise in the critical range. If the creatinine is at the critical value caused by chronic kidney disease, the creatinine may rise subsequently. When creatinine is at the critical value, the glomerular filtration rate may have significantly decreased. At this time, 24h UP quantification, endogenous creatinine clearance, and urine microalbumin can be checked to assess the patient’s condition.