The treatment of liver malignant tumors is complicated and generally divided into radical surgery or intervention-based comprehensive treatment. In the absence of distant metastasis and vascular invasion, especially for small hepatocellular carcinoma in the absence of thrombosis, radical surgery is the main treatment. It has also been reported that for small hepatocellular carcinoma <3 cm, radiofrequency ablation can achieve the same effect as surgery, but sufficient data are needed to support it. When hepatocellular carcinoma has distant metastasis or combined with inferior vena cava or portal trunk cancer thrombosis, the disease is obviously advanced and not suitable for radical surgery. At this time, interventional therapy, targeted immunotherapy, as well as chemotherapy, radiotherapy, biotherapy and other comprehensive treatments can be chosen, and such comprehensive treatments can prolong the patient's life and improve the quality of life, and all these treatment prerequisites need to be carried out under MDT (multidisciplinary comprehensive treatment) model.