It is a common allergic skin disease in children and is clinically characterized by scattered, firm, apical papules with small blisters surrounded by a fusiform red halo and self-induced pruritus. It is now mostly associated with an allergic reaction to the bite of fleas, bedbugs, mosquitoes, mites, etc. The disease needs to be differentiated from chicken pox, urticaria, hand, foot and mouth disease, etc. For the treatment of the disease, antihistamines can be given orally and topical glycopyrrolate lotion. Treatment must be accompanied by attention to the factors affecting the living environment: frequent sunbathing, spraying insecticides inside and outside the house, and trying not to keep pets such as dogs and cats. It is important to prevent scratching caused by itching and the secondary development of impetigo. Therefore, when this disease occurs, it is important to take the child to the hospital for timely treatment. The pigmentation that remains after clinical healing takes a long time to disappear. As children grow older, they can be desensitized after several years of repeated bites, so parents need not worry too much.